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08 Mar 2024: T-DXd (Enhertu) exhibits intracranial activity in HER2+ breast cancer brain metastases meta-analysis
- A systematic review and meta-analysis revealed significant intracranial activity of T-DXd (Enhertu) in HER2+ breast cancer brain Mets across all subgroups, emphasizing its efficacy
- Meta-analysis across 10 studies (n = 319) indicates a 61% ORR and intracranial ORR (IC-ORR ) with Enhertu
Investigators observed no significant differences in ORR and IC-ORR between the clinical trials and observational studies included in this meta-analysis
T-DXd is suggested as a second-line treatment for HER2-positive breast cancer with stable and active brain metastases.
