Kinase inhibitors are one of the major categories of cancer targeted therapy and one of the most active areas of research now. These represents a broad category of drugs with majority of them acting on tyrosine kinases. Tyrosine kinases are a part of many cell functions, including cell signaling, growth, and division, found at high levels in some types of cancer cells, and inhibiting them may help keep cancer cells from growing. Of the broad category of kinase inhibitors, in this digest we are covering the recent updates from MET kinase and Bruton tyrosine kinase inhibitors