Weekly Digest - June 2025

Weekly Digest - June 2025

24 June 2025: Dong-A ST files IND for Phase 1 clinical trial of ADC candidate for cancer

  • Dong-A ST’s ADC subsidiary, Aptis, has submitted an IND application in South Korea for DA-3501 (AT-211), a candidate targeting difficult-to-treat solid tumors such as gastric and pancreatic cancers, to initiate Phase 1 trials
  • DA-3501 targets Claudin 18.2, a protein overexpressed in certain cancer cells, and is designed to enhance efficacy in treating gastric and pancreatic cancers
  • The ADC utilizes Aptis’s proprietary AbClick platform technology, which is expected to provide enhanced selectivity and safety over existing ADCs
  • The submission marks a key milestone in Dong-A ST’s move into next-generation oncology therapeutics, with Aptis set to progress DA-3501 through early-phase development in South Korea

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