Weekly Digest - June 2025
CAR-T Digest - August 2020
CAR-T Digest - August 2020
CAR-T Digest - August 2020
CAR-T Digest - August 2020
Weekly Digest - June 2025
16 June 2025: NextCure and Simcere Zaiming announce strategic partnership for a novel antibody-drug conjugate targeting CDH6
- NextCure and Simcere Zaiming have partnered to develop SIM0505, a novel CDH6-targeting ADC for solid tumors. It’s in Phase 1 trials in China, with U.S. trials planned for Q3 2025
- SIM0505 uses a unique CDH6 epitope and Simcere’s proprietary topoisomerase I inhibitor (TOPOi) payload, designed for enhanced tumor binding and a wider therapeutic window
- A global dose expansion study is planned post dose escalation already U.S. FDA has cleared the IND application
- Simcere Zaiming may receive up to $745M in milestones and tiered royalties (up to double digits) on sales outside Greater China
