Weekly Digest - November 2024
CAR-T Digest - August 2020
CAR-T Digest - August 2020
CAR-T Digest - August 2020
CAR-T Digest - August 2020
Weekly Digest - November 2024
06 Nov 2024: NextCure reports preclinical data for LNCB74 and additional clinical biomarker data for NC410 combo at Society for Immunotherapy of Cancer Annual Meeting
- NextCure announced preclinical data for LNCB74, a B7-H4-targeting ADC developed with LigaChem Biosciences, to be presented at the SITC annual meeting
- The company highlighted LNCB74’s potential as a best-in-class therapy, with plans to submit an IND application to the FDA by year-end
- LNCB74 combines a B7-H4 antibody with MMAE using LigaChem’s ConjuAll™ technology, achieving a 4:1 drug-to-antibody ratio for enhanced stability, selective payload release, and minimized off-target effects
- The ADC showed strong anti-tumor activity in multiple tumor models, with durable regression at 3 mg/kg, outperforming existing B7-H4 ADCs
